DUKE UNIVERSITY
SCHOOL OF MEDICINE
DUKEHEALTH.ORG
| Faculty & Staff |
Hans-Ewald Hohmeier, MD, PhD
Assistant Research Professor
Department of Medicine
Division of Endocrinology, Metabolism, and Nutrition
Division of Endocrinology, Metabolism, and Nutrition
Hans Hohmeier, MD, PhD was recruited to the Sarah W. Stedman Nutrition and Metabolism Center in 2002 as assistant research professor with a primary appointment in the Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition. Before joining the Stedman Center, he spent 6 years developing engineered cell lines for the treatment of metabolic diseases at βGene, Inc., where he was a project leader. He trained at the Medical School Hannover, Germany and did his thesis work in Immunochemistry with Dr. N. Hilschmann at the Max-Planck Institute for Experimental Medicine in Goettingen, Germany. In 1992, he joined the Touchstone Center for Diabetes Research at UT Southwestern Medical Center in Dallas as a postdoctoral fellow training with Drs. J.D. Capra and C.B. Newgard. His research focuses on pathways of glucose- stimulated insulin secretion in the β-cell and the protection of β-cells against cytotoxic and lipotoxic stress. He is a co-investigator on the Duke component of an NIH β-cell consortium grant.
Publications:
Chen S, Ding JH, Bekeredjian R, Yang BZ, Shohet RV, Johnston SA, Hohmeier HE, Newgard CB, Grayburn PA. Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology. Proc Natl Acad Sci U S A. 2006 May 30;103(22):8469-74. Epub 2006 May 18.
Collier JJ, Fueger PT, Hohmeier HE, Newgard CB. Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines. Diabetes. 2006 May;55(5):1398-406.
Hohmeier H, Newgard CB. Islets for all? Nature Biotechnol. 2005;23(10):1231-1232.
Hohmeier H, Newgard CB. Cell lines derived from pancreatic islets. Mol Cell Endocrinol. 2004;228:121-128.
Newgard CB, Hohmeier H, Lu D, Jensen MV, Tran VV, Chen G, Burgess S, Sherry AD. Understanding the basic mechanisms of β-cell function and survival: prelude to new diabetic therapies. Cell Biochem Biophys. 2004;40 (Suppl 3):159-168.
Yang S, Fransson U, Fagerhus L, Holst LS, Hohmeier HE, Renstrom E, Mulder H: Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13). Mol Endocrinol. 2004;18:2312-2320.
Hohmeier HE, Tran VV, Chen G, Gasa R, Newgard CB: Inflammatory mechanisms in diabetes: lessons from the beta-cell. Int J Obes Relat Metab Disord. 2003;2 :S12-6.
Tran V, Chen G, Newgard CB, Hohmeier HE. Discrete and complementary mechanisms of protection against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy. Diabetes. 2003;52:1423-1432.
Hohmeier HE, Mulder H, Chen G, Prentki M, Newgard CB. Isolation of INS-1 derived cell lines with robust K ATP channel-dependent and independent glucose stimulated insulin secretion. Diabetes. 2000;49:424-430.
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