Faculty & Staff

Tim Koves, Ph.D., MBA

Assistant Research Professor

Dept. of Medicine, Division of Geriatrics

koves001@mc.duke.edu

Dr. Tim Koves is an Assistant Research Professor in the Sarah. W. Stedman Nutrition and Metabolism Center, with a primary appointment in the Department of Medicine, Division of Geriatrics. He earned his Ph.D. in physiology from the Brody School of Medicine at East Carolina University where he studied the regulation of lipid oxidation in skeletal muscle mitochondria. He came to Duke in 2002 for post-doctoral training in the laboratory of Dr. Debbie Muoio where he developed his interests in mitochondrial metabolism and how it changes with metabolic diseases such as obesity and type 2 diabetes. He joined the faculty in 2006 and continues to work closely with Dr. Muoio. His long-term goals are 1) to develop strategies that will preserve skeletal muscle mitochondria function during the aging process and 2) to understand how enhanced mitochondrial function may protect against age-induced decrements in muscle strength and aerobic capacity. He has received past funding from the John A. Hartford Foundation and his aging research is currently funded by a New Scholar grant from the Ellison Medical Foundation.

Publications:

1. Li LO, Ellis JM, Paich HA, Wang S, Gong N, Altshuller GN, Thresher RJ, Koves TR, Watkins SM, Muoio DM, Cline GW, Shulman GI, Coleman RA. Liver-specific loss of long-chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation, and alters phospholipid fatty acid composition. J Biol Chem. 2009 Aug 1.

2. Noland RC, Koves TR, Seiler SE, Lum H, Lust RM, Ilkayeva O, Stevens RD, Hegardt FG, Muoio DM. Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J Biol Chem. 2009 Aug 21;284(34):22840-52.

3. Ussher JR, Koves TR, Jaswal JS, Zhang L, Ilkayeva O, Dyck JR, Muoio DM, Lopaschuk GD. Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase. Diabetes. 2009 Aug;58(8):1766-75.

4. Noland RC, Koves TR, Seiler SE, Lum H, Lust RM, Ilkayeva O, Stevens R, Hegardt FG, Muoio DM. Carnitine Insufficiency Caused by Aging and Overnutrition Compromises Mitochondrial Performance and Metabolic Control. J Biol Chem. 2009 Jun 24.

5. Makowski L, Noland RC, Koves TR, Xing W, Ilkayeva OR, Muehlbauer MJ, Stevens RD, Muoio DM. Metabolic profiling of PPAR{alpha}-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. FASEB J. 2008 Oct 22.

6. Muoio DM, Koves TR. Lipid-induced metabolic dysfunction in skeletal muscle. Novartis Found Symp. 2007;286:24-38; discussion 38-46, 162-3, 196-203.

7. Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, Bain J, Stevens R, Dyck JR, Newgard CB, Lopaschuk GD, Muoio DM. Mitochondrial overload and incomplete Fatty Acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 2008 Jan;7(1):45-56.

8. Muoio DM, Koves TR. Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic disease. Appl Physiol Nutr Metab. 2007 Oct;32(5):874-83. Review.

9. Thyfault JP, Cree MG, Zheng D, Zwetsloot JJ, Tapscott EB, Koves TR, Ilkayeva O, Wolfe RR, Muoio DM, Dohm GL. Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism. Am J Physiol Cell Physiol. 2007 Feb;292(2):C729-39.

10. Gaillard S, Grasfeder LL, Haeffele CL, Lobenhofer EK, Chu TM, Wolfinger R, Kazmin D, Koves TR, Muoio DM, Chang CY, McDonnell DP. Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs. Mol Cell. 2006 Dec 8;24(5):797-803.

11. Koves TR, Li P, An J, Akimoto T, Slentz D, Ilkayeva O, Dohm GL, Yan Z, Newgard CB, Muoio DM. Peroxisome proliferator-activated receptor-{gamma} co-activator 1{alpha}-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem. 2005 Sep 30;280(39):33588-98.

12. Berggren JR, Tanner CJ, Koves TR, Muoio DM, Houmard JA. Glucose uptake in muscle cell cultures from endurance-trained men. Med Sci Sports Exerc. 2005 Apr;37(4):579-84.

13. Koves TR, Noland RC, Bates AL, Henes ST, Muoio DM, Cortright RN. Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism. Am J Physiol Cell Physiol. 2005 May;288(5):C1074-82.

14. Fluckey JD, Cortright RN, Tapscott E, Koves T, Smith L, Pohnert S, Dohm GL. Active involvement of PKC for insulin-mediated rates of muscle protein synthesis in Zucker rats. Am J Physiol Endocrinol Metab. 2004 May;286(5):E753-8.

15. An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI, Koves TR, Stevens R, Millington D, Newgard CB. Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat Med. 2004 Mar;10(3):268-74.

16. Kim JY, Koves TR, Yu GS, Gulick T, Cortright RN, Dohm GL, Muoio DM. Evidence of a malonyl-CoA insensitive carnitine palmitoyltransferase I activity in red skeletal muscle. Am J Physiol Endocrinol Metab. 2002 May;282(5):E1014-22.

17. Tanner CJ, Koves TR, Cortright RL, Pories WJ, Kim YB, Kahn BB, Dohm GL, Houmard JA. Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men. Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E147-53.

	Disclaimer Duke & Your Privacy © 2009, Duke University Health System
	DHTS STRATEGIC WEB SERVICES