|Faculty & Staff|
Christopher B. Newgard, PhD
Director, Sarah W. Stedman Nutrition and Metabolism Center
W. David and Sarah W. Stedman Distinguished Professor
Professor of Pharmacology and Cancer Biology
Professor of Medicine
Christopher Newgard, PhD has served as director of the Sarah W. Stedman Nutrition and Metabolism Center since March 2002. Prior to coming to Duke, Dr. Newgard was the Gifford O. Touchstone and Randolph G. Touchstone Distinguished Professor and co-director of the Touchstone Center for Diabetes Research at UT Southwestern Medical Center in Dallas. Before his appointment as director of the Stedman Center, the Stedman Center was recognized as a clinical research center. Since taking over the leadership of the center, Dr. Newgard has combined a strong basic science research program in metabolism with a new clinical research program focused on nutrition, metabolism, and obesity. To these programs he has added a comprehensive metabolic and biomarker profiling program to put the Stedman Center on an entirely new trajectory for success. A pillar of the basic science research program of the Stedman Center is Dr. Newgard’s own laboratory. His laboratory focuses on understanding metabolic regulatory mechanisms and applying this knowledge to gain insight into chronic conditions and diseases such as obesity and diabetes. Key projects in the lab include the following: 1) mechanisms involved in the regulation of insulin secretion from pancreatic islet β-cells by glucose and other metabolic fuels; 2) mechanisms involved in obesity-related impairment of β -cell function; 3) development of methods for protection of β cells against environmental insults, including elevated lipids and inflammatory mediators; 4) studies on spatial organization and regulation of systems controlling hepatic glucose balance; 5) studies on the mechanisms involved in lipid-induced impairment of insulin action in obesity and diabetes.
Ferrara, CT, Wang P, Stevens, RD, Neto EC, Bain JR, Choi Y, Keller MP, Kendziorski CM, Yandell BS, Wenner BR, Oler AT, Basiole DA, Ilkayeva OR, Newgard, CB*, Attie, AD*. 2008. Genetic networks of liver metabolism revealed by integration of metabolic and transcriptomic profiling. PLoS Genetics 4: e1000034. *Co-senior authors
Schisler J, Fueger, P. T., Babu, D. A., Hohmeier, H.E., Tessem, J. S., Lu, D., Becker, T.C., Naziruddin, B., Levy, M., Mirmira R.G., and Newgard CB. 2008. Stimulation of human and rat islet-bell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. Molecular and Cellular Biology 28: 3465-3476.
Muoio D.M., Newgard C.B. 2008. Molecular and metabolic mechanisms of insulin resistance and b-cell failure in type 2 diabetes. Nature Reviews Molecular Cell Biology 9: 193-205.
Chopra, A., Louet, J-F., Saha, P., DMayo, F., Xu, J., York, B., Sarpen, S., Finegold, M., Moore, D., Chan, L., An, J., Newgard, C.B., O’Malley, B.W. 2008. Steroid receptor coactivator SRC-2 governs hepatic glucose production and its absence results in Von Gierke’s disease. Science 322: 1395-1399.
Newgard, C.B., An, J., Bain, J.R., Muehlbauer, M.J., Stevens, R.D., Lien, L.F., Haqq, A.M., Shah, S.H., Arolotto, M., Slentz, C.A., Rochon, J., Gallup, D., Ilkayeva, O., Wenner, B.R., Yancy, W.E., Eisenson, H., Musante, G., Surwit, R., Millington, D.S., Butler, M.D., Svetkey, L.P. 2009. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metabolism 9: 311-326.
Bain, J.R., Stevens, R.D., Wenner B.R., Ilkayeva, O., Muoio, D.M., Newgard, C.B. 2009. Metabolomics applied to diabetes research: Moving from information to knowledge. Diabetes 58: 2429-2443.
Shah, S.H., Bain, J., Crosslin, D.R., Muehlbauer, M.J., Stevens, R., Haynes, C., Dungan, J., Newby, L.K., Hauser, E.R., Ginsburg, G.S., Newgard, C.B., Kraus, W.E. 2010. Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events. Circulation Cardiovascular Genetics 3: 207-214.
Odegaard, ML, Joseph JW, Jensen, M.V., Lu, D., Ilkayeva, O., Ronnebaum, S.M., Becker, T.C., Newgard, C.B. 2010. The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion. Journal of Biological Chemistry 285: 16530-16537.
Kelly P., Bailey C.L., Fueger, P.T., Newgard, C.B., Casey, P.J., Kimple M.E. 2010. Rap1 promotes multiple pancreatic islet cell functions and signals through mTOR complex 1 to enhance proliferation. Journal of Biological Chemistry 285: 15777-15785
Louet JF, Chopra AR, Sagen JV, An J, York B, Tannour-Louet M, Saha PK, Stevens RD, Wenner BR, Ilkayeva OR, Bain JR, Zhou S, Demayo F, Xu J, Newgard CB, O’Malley BW. 2010. The coactivator SRC-1 is an essential coordinator of hepatic glucose production. Cell Metabolism 12:606-618.
Newgard, C.B. and Attie, A.D. 2010. Getting biologic about the genetics of diabetes. Nature Medicine 16: 388-391.
LaFerrere, B., Arias, S., Swerdlow, N., Gorroochurn P., Bose, M., Bawa, B., Tiexeira J., Stevens, R.D., Wenner, B.R., Bain, J.R., Muehlbauer, M.J., Haqq, A., Lien, L., Shah, S., Svetkey, L.S., Newgard, C.B. 2011. Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss. Science Translational Medicine, 3: 80re2.