DUKE UNIVERSITY
SCHOOL OF MEDICINE
DUKEHEALTH.ORG
| Faculty & Staff |
Jeffrey Rathmell, PhD
Assistant Professor
Dept. of Pharmacology and Cancer Biology
Jeffrey Rathmell, PhD was recruited to the Sarah W. Stedman Nutrition and Metabolism Center as a tenure-track assistant professor in May 2003. His primary academic appointment is in the Department of Pharmacology and Cancer Biology at Duke University Medical Center. He received his graduate training from Dr. Chris Goodnow at Stanford University and his post-doctoral training from Dr. Craig Thompson at the University of Pennsylvania. He has published landmark papers in outstanding journals during both training experiences. His research program is now focused on nutritional modulation of immune system function, particularly the mechanisms and role of glucose metabolism in lymphocytes. Expression and localization of Glut1, a glucose transporter, and the role of glucose uptake on cell death via regulation of the Bcl-2 family of proteins are two current interests of his laboratory.
Publications:
MacIver, N.J., S.R. Jacobs, H.L. Wieman, J.A. Wofford, J.L. Coloff, J.C. Rathmell. 2008. Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. J Leukoc Biol. 2008 Jun 24. [Epub ahead of print]. PMID: 18577716
Jacobs, S.R., C.E. Herman, J. Hammen, J.C. Rathmell. 2008. Glucose Uptake is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and -Independent Pathways. J. Immunol. 180:4476-86. PMID: 18354169
Wofford, J.A., H.L. Wieman, S.R. Jacobs, Y. Zhao, J.C. Rathmell. 2007. IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt1 to support T cell survival. Blood. 111:2101-2111. PMCID: PMC2234050
Juntilla, M.M*, J.A. Wofford*, M.J. Birnbaum, J.C. Rathmell, G Koretzky. 2007. Akt1 and Akt2 are required for immature ab thymocyte survival and differentiation. Proc. Natl. Acad Sci USA. 104:12105-10. *These authors contributed equally. Note that J.A. Wofford is a student in the Rathmell lab and J.C. Rathmell and G. Koretzky are listed as co-corresponding authors on this manuscript. PMCID: PMC1924580
Zhao, Y., B.J. Altman, J.L. Coloff, C.E. Herman, S.R. Jacobs, H.L. Wieman, J.A. Wofford, L.N. Dimascio, O. Ilkayeva, A. Kelekar, T. Reya, and J.C. Rathmell. 2007. GSK-3a/ß Mediate a Glucose-Sensitive Anti-Apoptotic Signaling Pathway to Stabilize Mcl-1. Mol Cell Biol. 27:4328-39. PMCID: PMC1900055
Wieman, H.L., J.A. Wofford, J.C. Rathmell. 2007. Cytokine Stimulation Promotes Glucose Uptake via Phosphatidylinositol-3 kinase/Akt Regulation of Glut1 Activity and Trafficking. Mol. Biol. Cell. 18:1437-46. PMCID: PMC1838986
Nutt, L.K., S.S. Margolis, M. Jensen, C.E. Herman, W.G. Dunphy, J.C. Rathmell, S. Kornbluth. 2005. Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of Caspase 2. Cell. 123:89-103. Article selected for cover art. See comment in Cell 123:3-5.
Rathmell, J.C., C. J. Fox, D.R. Plas, P. Hammerman, R.M. Cinalli, C.B. Thompson. 2003. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol. Cell. Biol. 23:7315-7328.
Rathmell, J.C., C.B. Thompson. 2002. Pathways of apoptosis in lymphocyte development, homeostasis, and disease. Cell 109:S97-S107.
Rathmell, J.C., M.G. Vander Heiden, M.H. Harris, K.A. Frauwirth, C.B. Thompson. 2000. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol. Cell 6:683-692.
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